Pantothen was created based on the research of Dr. Lit-Hung Leung, who published his first study on the relationship between Pantothenic Acid and acne treatment in 1997. In the 13 years since his study was made available, it has stood the test of time and has not been conclusively challenged by any reliable medical source.

His findings were published in the well-respected Journal Of Orthomolecular Medicine. Dr. Leung used Pantothenic Acid on a variety of test subjects. The majority of them started to see measurable results within one to two weeks of starting treatment. He tried both oral and topical applications of Pantothenic Acid and notice greater results with the oral program, demonstrating that it is an internal acne reduction process.